PMID31149153

PMID31149153 : COMPARISON OF FINASTERIDE, METFORMIN, AND FINASTERIDE PLUS METFORMIN IN PCOS.

Abstract

The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin treatments on hormone levels, insulin resistance, and hirsutism score in women with PCOS. Fifty-two patients with PCOS were randomly assigned to receive finasteride 5 mg/day, metformin 1700 mg/day or finasteride plus metformin for 12 months. Body mass index (BMI), Ferriman Gallway score (FGS), serum concentrations of estradiol, sex hormone-binding globulin, free testosterone, dehydroepiandrosterone sulfate (DHEAS), androstenedione, and homeostasis model assessment of insulin resistance (HOMA-IR) index and areas under the curve (AUC) for insulin and glucose were evaluated before and after 12 months of treatment. Reductions in FGS, free testosterone, DHEAS, androstenedione, HOMA-IR, AUC-insulin, and AUC-glucose were significant within each group, whereas BMI and estradiol were not. Comparisons of changes in parameters in the 3 groups did not clearly show the superiority of any treatment modality. The treatment with finasteride alone significantly reduced both androgen levels and parameters of insulin resistance. In addition, metformin alone was effective, and not inferior to finasteride, in the treatment of hyperandrogenism.

Structured Findings

Finasteride 5 mg/day, metformin 1700 mg/day or finasteride plus metformin for 12 months significantly decreased Ferriman Gallway score (FGS), free testosterone, DHEAS, androstenedione, HOMA-IR, AUC-insulin, and AUC-glucose compared to Finasteride 5 mg/day, metformin 1700 mg/day or finasteride plus metformin for 12 months

Structured Markup

Intervention	Comparator	Outcome	Label
Finasteride 5 mg/day, metformin 1700 mg/day or finasteride plus metformin for 12 months	Finasteride 5 mg/day, metformin 1700 mg/day or finasteride plus metformin for 12 months	Ferriman Gallway score (FGS), free testosterone, DHEAS, androstenedione, HOMA-IR, AUC-insulin, and AUC-glucose	significantly decreased