PMID29544572

PMID29544572 : Effect of Metformin Alone Compared with Metformin Plus Simvastatin on Polycystic Ovarian Syndrome in Pakistani Women.

Abstract

OBJECTIVE To determine the efficacy of metformin alone versus metformin plus simvastatin for treatment of polycystic ovariansyndrome (PCOS). STUDY DESIGN Randomized controlled trial. PLACE AND DURATION OF STUDY Maternal and Child Health Centre, Unit II, Pakistan Institute of Medical Sciences (PIMS), from November 2014 to April 2015. METHODOLOGY One hundred and eight patients (108) were randomly divided into metformin group (n=54) and metformin plus simvastatin group (n=54), detailed clinical history, including menstrual details, was taken with thorough examination performed. Baseline ultrasound was performed to evaluate ovarian size and these were considered enlarged with volume >10cc or with >12 follicles in any one ovary. Blood samples were taken at baseline and after three months of therapy to determine the LH/FSH ratio and lipid profile. Efficacy was defined as >15% decrease in the baseline values. RESULTS The mean age of patients was 28.82 ±7.18 years. Mean BMI of the patients was 22.41 ±1.55 Kg/m2. Efficacy was achieved in 66.7% patients with metformin alone, while in 92.6% with combination medication (p=0.001). CONCLUSION The combination of metformin plus simvastatin is more efficacious as compared to metformin alone for management of females with PCOS.

Structured Findings

Metformin plus simvastatin significantly increased Efficacy compared to Metformin alone

Structured Markup

Intervention	Comparator	Outcome	Label
Metformin plus simvastatin	Metformin alone	Efficacy	significantly increased